04/09/2003

‘Full’ hormone could be key to slimming

There is hope that important hormone messengers, which tell the brain when to stop eating, could provide the key to produce a new slimming treatment.

Researchers from the UK have discovered that obese people tend to have lower levels of a hormone fragment PYY3-36, which is known to be an important chemical messenger that tells the body to stop eating.

Comparing the discovery to that of insulin, Professor Stephen Bloom of Imperial College London, a co-author of the research paper, said that it was the first time in over 20 years that a natural compound had been identified with such potential for a medical application.

The research team from Imperial College and Hammersmith in London found that a sample of both fat and thin volunteers who were given an intravenous infusion of PYY3-36 felt less hungry and eat less in the day they received the infusion, than those in a control group given a saline placebo.

However, medical experts have warned that this form of treatment, if it were to be licensed, would not be a substitute for a healthy balanced diet and exercise.

The chairman of the National Obesity Forum, Dr Ian Campbell, said that previous “breakthroughs” had raised hopes of better treatments for obesity, but that none had yet proven effective.

Previous obesity treatment claims made in 1997 focused on leptin - another naturally occurring substance in the human body that is known to play a role in signalling the quantity of fat stored in the body. For reasons not yet fully understood, obese people are more resistant to its potentially beneficial action.

(SP)

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